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We'll be in Ed2 South Rm. 2305

Units 9/10 notes updated, 2011
Supplements updated, 2011

About interferons
IFNγ is the only Type II interferon; there are about 20 IFNα's, and 1 IFNβ. IFNγ drives the differentiation of macrophages into M1.

Type I IFNs, which increase cellular resistance to viral infection, can perversely decrease bacterial resistance; this may explain the tendency for bacterial superinfection in, for example, influenza (especially notable in the 1918 Spanish Flu pandemic, where more than 25% of deaths were from secondary bacterial pneumonia).

 

WEEK 5: 4 October

Unit 9: T Cells 1 Download the PDF

Unit 10: T Cells 2 (same notes as T Cells 1)

Supplemental material (optional): T Cell Supplementary Material 2011
Supplemental material (optional): TCR footprints on MHC

An overall diagram of T cells and their interactions